HtslibApplication

CVE-2026-31964

HIGH · 7.5 CVSS v3.1 Published 2026-03-18
Fix available
A fix is available. Upgrade to 1.21.1 / 1.22.2 or later.
See remediation →
84/100
Remediation priority · High
Remotely reachable No privileges Zero-click Patch available

Official description Straight from the sourceThe vendor's or NVD's own wording, published unedited. Authoritative, but often terse — it says what broke, rarely what to do.

NVD · unedited
HTSlib is a library for reading and writing bioinformatics file formats. CRAM is a compressed format which stores DNA sequence alignment data using a variety of encodings and compression methods. While most alignment records store DNA sequence and quality values, the format also allows them to omit this data in certain cases to save space. Due to some quirks of the CRAM format, it is necessary to handle these records carefully as they will actually store data that needs to be consumed and then discarded. Unfortunately the `CONST`, `XPACK` and `XRLE` encodings did not properly implement the interface needed to do this. Trying to decode records with omitted sequence or quality data using these encodings would result in an attempt to write to a NULL pointer. Exploiting this bug causes a NULL pointer dereference. Typically this will cause the program to crash. Versions 1.23.1, 1.22.2 and 1.21.1 include fixes for this issue. There is no workaround for this issue.

Technical summary Written by usOur analysis, written from the advisory, the CVSS vector and the affected-version data. It adds context the advisory leaves out, and never invents facts that are not in the source.

dbcve analysis
How this class of weakness works · CWE-476

The code follows a pointer that is null, crashing the process. An attacker who can reliably trigger it turns the crash into a denial of service. The fix is checking for null before use and handling the failure path gracefully.

General guidance for the null pointer dereference class — the official description and references above are authoritative for this specific CVE. Want a bespoke review and a reviewed fix? Ask our team →

Affected products & versions What the vendor confirmedThe version ranges the vendor confirmed as vulnerable. If your version sits inside a range here, treat yourself as exposed until you have upgraded.

NVD · CPE data
HtslibApplication
Affected:< 1.21.1>= 1.22, < 1.22.2= 1.23

CVSS breakdown How the score is builtThe industry scoring standard. It rates how the flaw is reached, what it takes to exploit, and what an attacker gains — the score is derived from those, not the other way round.

From the vector
Attack vector
Network
Complexity
Low
Privileges
None
User interaction
None
Scope
Unchanged
Confidentiality
None
Integrity
None
Availability
High

CVSS:3.1/AV:N/AC:L/PR:N/UI:N/S:U/C:N/I:N/A:H

Remediation Closing itWhat it takes to close this. Where a vendor fix exists we point at it; where none exists we say so plainly, and can build one. Effort estimates are scoped from the advisory, not from your codebase.

dbcve · scoped
Upgrade available Upgrade to 1.21.1 / 1.22.2 or later
Fixed in 1.21.11.22.2
Vendor patch github.com →
Recommended fix High confidence

htslib 1.23.1 (or 1.22.2 / 1.21.1)

  1. Identify the current version of htslib in use by checking your project's dependencies or the installed library version
  2. Upgrade htslib to version 1.21.1, 1.22.2, or 1.23.1 (recommended: 1.23.1 for latest fixes)
  3. Rebuild and redeploy any applications or services that depend on htslib

Generated from the published advisory — verify against the referenced sources before acting.

We can perform the upgrade in your staging environment and verify nothing breaks — typical engagement from $3,200. Get the upgrade done

Scan for this in your stack

Free · runs locally
dbcve dependency scanner

Check whether your project pulls in CVE-2026-31964 — or any other known-vulnerable package — straight from your lock files. Free and open source; it runs locally and uploads nothing.

References Go to the primary sourcePrimary sources — vendor advisories, patches and trackers. Where our summary and a reference disagree, the reference wins.

Primary sources

Practitioner notes

Contributed

Peer-ranked notes from engineers who’ve handled CVE-2026-31964 in production — separate from our analysis above.

No notes yet

Be the first to add a field note for this CVE — a mitigation you’ve verified, a version caveat, or a link to a working fix. Sign in above to contribute.

What this is

A place for practitioners to share what actually worked: a mitigation you’ve tested, a configuration change, a version- or environment-specific caveat, or a link to a verified patch. The most useful notes rise to the top as peers upvote them, so the signal stays high.

What belongs here
  • Verified mitigations, workarounds, and config changes
  • Version or environment caveats, and links to real fixes
  • No weaponised exploit code, or anything meant to cause harm
  • No spam, self-promotion, credentials, or personal data