HtslibApplication

CVE-2026-31968

HIGH · 8.1 CVSS v3.1 Published 2026-03-18
Fix available
A fix is available. Upgrade to 1.21.1 / 1.22.2 or later.
See remediation →
88/100
Remediation priority · High
Remotely reachable No privileges Patch available

Official description Straight from the sourceThe vendor's or NVD's own wording, published unedited. Authoritative, but often terse — it says what broke, rarely what to do.

NVD · unedited
HTSlib is a library for reading and writing bioinformatics file formats. CRAM is a compressed format which stores DNA sequence alignment data using a variety of encodings and compression methods. For the `VARINT` and `CONST` encodings, incomplete validation of the context in which the encodings were used could result in up to eight bytes being written beyond the end of a heap allocation, or up to eight bytes being written to the location of a one byte variable on the stack, possibly causing the values to adjacent variables to change unexpectedly. Depending on the data stream this could result either in a heap buffer overflow or a stack overflow. If a user opens a file crafted to exploit this issue it could lead to the program crashing, overwriting of data structures on the heap or stack in ways not expected by the program, or changing the control flow of the program. It may be possible to use this to obtain arbitrary code execution. Versions 1.23.1, 1.22.2 and 1.21.1 include fixes for this issue. There is no workaround for this issue.

Technical summary Written by usOur analysis, written from the advisory, the CVSS vector and the affected-version data. It adds context the advisory leaves out, and never invents facts that are not in the source.

dbcve analysis
How this class of weakness works · CWE-121

Data overflows a fixed-size buffer allocated on the stack, overwriting adjacent stack memory — including saved return addresses — which is the classic route to redirecting execution into attacker-supplied code. Crafted input is all it takes. Remediation is strict length checks, safe bounded string and memory functions, and modern stack-protection mitigations.

General guidance for the stack-based buffer overflow class — the official description and references above are authoritative for this specific CVE. Want a bespoke review and a reviewed fix? Ask our team →

Affected products & versions What the vendor confirmedThe version ranges the vendor confirmed as vulnerable. If your version sits inside a range here, treat yourself as exposed until you have upgraded.

NVD · CPE data
HtslibApplication
Affected:< 1.21.1>= 1.22, < 1.22.2= 1.23

CVSS breakdown How the score is builtThe industry scoring standard. It rates how the flaw is reached, what it takes to exploit, and what an attacker gains — the score is derived from those, not the other way round.

From the vector
Attack vector
Network
Complexity
Low
Privileges
None
User interaction
Required
Scope
Unchanged
Confidentiality
None
Integrity
High
Availability
High

CVSS:3.1/AV:N/AC:L/PR:N/UI:R/S:U/C:N/I:H/A:H

Remediation Closing itWhat it takes to close this. Where a vendor fix exists we point at it; where none exists we say so plainly, and can build one. Effort estimates are scoped from the advisory, not from your codebase.

dbcve · scoped
Upgrade available Upgrade to 1.21.1 / 1.22.2 or later
Fixed in 1.21.11.22.2
Vendor patch github.com →
Recommended fix High confidence

Upgrade to htslib version 1.23.1 (latest fixed release), or alternatively versions 1.22.2 or 1.21.1

  1. Identify the current htslib version in use by running 'htslib --version' or checking library version linked to applications
  2. Download the fixed release (1.23.1, 1.22.2, or 1.21.1) from the official htslib repository at https://github.com/samtools/htslib/releases
  3. Extract the source archive and navigate to the extracted directory
  4. Run './configure' to prepare the build configuration
  5. Run 'make' to compile the fixed version
  6. Run 'make install' to install the updated library (or use 'sudo make install' if root permissions are required)
  7. Rebuild any applications that statically or dynamically link against htslib to ensure they use the patched library
  8. Verify the installed version matches one of the fixed releases (1.23.1, 1.22.2, or 1.21.1)
Caveat Minor: Ensure any downstream tools (e.g., samtools, bcftools) are compatible with the new htslib version; some API users may need recompilation

Generated from the published advisory — verify against the referenced sources before acting.

We can perform the upgrade in your staging environment and verify nothing breaks — typical engagement from $1,950. Get the upgrade done

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References Go to the primary sourcePrimary sources — vendor advisories, patches and trackers. Where our summary and a reference disagree, the reference wins.

Primary sources

Practitioner notes

Contributed

Peer-ranked notes from engineers who’ve handled CVE-2026-31968 in production — separate from our analysis above.

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What this is

A place for practitioners to share what actually worked: a mitigation you’ve tested, a configuration change, a version- or environment-specific caveat, or a link to a verified patch. The most useful notes rise to the top as peers upvote them, so the signal stays high.

What belongs here
  • Verified mitigations, workarounds, and config changes
  • Version or environment caveats, and links to real fixes
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